Most and least shorted healthcare stocks with up to $2B market cap

Short interest in small-cap healthcare surged toward the end of January, centering heavily on the biotechnology sector. Data as of January 30 shows that KalVista (KALV [https://seekingalpha.com/symbol/KALV]) and Intellia (NTLA [https://seekingalpha.com/symbol/NTLA]) have become the most shorted names in the $2 billion-and-under market cap tier, carrying short interest ratios of 39.23% and 36.74%, respectively.

Conversely, the "least-shorted" stocks, such as Syra Health (SYRA [https://seekingalpha.com/symbol/SYRA]) and Ernexa Therapeutics (ERNA [https://seekingalpha.com/symbol/ERNA]) currently maintain negligible short interest of just 0.51%, signaling stability among small-cap investors.

Healthcare stocks are outperforming the broader market so far this year. The Health Care Select Sector SPDR® Fund ETF (NYSEARCA:XLV [https://seekingalpha.com/symbol/XLV#hasComeFromMpArticle=false#source=section%3Amain_content%7Cbutton%3Abody_link%7Cfirst_level_url%3Anews]), which tracks the health care sector and holds a weightage of 12.12% in the S&P 500 index, has gained 1.85% in 2026. This stands in contrast to the S&P 500's overall 0.14% decline, signaling investor preference for healthcare over growth sectors.

HERE ARE THE FIVE MOST SHORTED HEALTHCARE STOCKS WITH MARKET CAPITALIZATIONS OF UP TO $2 BILLION (AS A % OF SHARES OUTSTANDING) AS OF JANUARY 30:

KalVista Pharmaceuticals (KALV [https://seekingalpha.com/symbol/KALV]) Biotechnology sector, short interest 39.23%

Intellia Therapeutics (NTLA [https://seekingalpha.com/symbol/NTLA]) Biotechnology sector, short interest 36.74%

Novavax (NVAX [https://seekingalpha.com/symbol/NVAX]) Biotechnology sector, short interest 32.79%

Recursion Pharmaceuticals (RXRX [https://seekingalpha.com/symbol/RXRX]) Biotechnology sector, short interest 31.77%

Tango Therapeutics (TNGX [https://seekingalpha.com/symbol/TNGX]) Biotechnology sector, short interest 31.75%

HERE ARE THE FIVE LEAST SHORTED HEALTHCARE STOCKS WITH MARKET CAPITALIZATIONS OF UP TO $2 BILLION (AS A % OF SHARES OUTSTANDING) AS OF JANUARY 30:
[Health Care Medical Stock Market Industry Sector Wall Street Buildings 3d Illustration]
iQoncept/iStock via Getty Images

Syra Health (SYRA [https://seekingalpha.com/symbol/SYRA]) Health Care Services, short interest 0.51%

Ernexa Therapeutics (ERNA [https://seekingalpha.com/symbol/ERNA]) Biotechnology sector, short interest 0.51%

Aprea Therapeutics (APRE [https://seekingalpha.com/symbol/APRE]) Biotechnology sector, short interest 0.51%

China Pharma Holdings (CPHI [https://seekingalpha.com/symbol/CPHI]) Pharmaceuticals sector, short interest 0.52%

Modular Medical (MODD [https://seekingalpha.com/symbol/MODD]) Health Care Equipment sector, short interest 0.52%

NOW READ: Most and least shorted mid-to mega-cap healthcare stocks in January [https://seekingalpha.com/news/4551065-most-and-least-shorted-mid-to-mega-cap-healthcare-stocks-in-january]

RELATED ETFS: Health Care Select Sector SPDR Fund (NYSEARCA:XLV [https://seekingalpha.com/symbol/XLV]), SPDR S&P Pharmaceuticals ETF (NYSEARCA:XPH [https://seekingalpha.com/symbol/XPH]), VanEck Pharmaceutical ETF (NASDAQ:PPH [https://seekingalpha.com/symbol/PPH]), iShares Nasdaq Biotechnology ETF (NASDAQ:IBB [https://seekingalpha.com/symbol/IBB]), iShares U.S. Pharmaceuticals ETF (NYSEARCA:IHE [https://seekingalpha.com/symbol/IHE]), and Invesco Nasdaq Biotechnology ETF (NASDAQ:IBBQ [https://seekingalpha.com/symbol/IBBQ]).

MORE ON SHORT INTEREST REPORT

* Most and least shorted mid-to mega-cap healthcare stocks in January [https://seekingalpha.com/news/4551065-most-and-least-shorted-mid-to-mega-cap-healthcare-stocks-in-january]
* Hims & Hers short interest climbs amid legal risk related to weight loss pill [https://seekingalpha.com/news/4552068-hims-hers-short-interest-rise-legal-risk#source=section%3Asummary%7Csection_asset%3Anews_news%7Cfirst_level_url%3Asymbol%7Cbutton%3ATitle%7Clock_status%3ANo%7Cline%3A1]
* HE, OTTR draw highest short interest in utilities sector; BIP and ES see lowest short interest [https://seekingalpha.com/news/4550316-he-ottr-draw-highest-short-interest-in-utilities-sector-bip-and-es-see-lowest-short-interest]
* Top Quant rated bullish small cap stocks among companies with high short interest [https://seekingalpha.com/news/4549737-top-quant-rated-bullish-small-cap-stocks-among-companies-with-high-short-interest]
* Most and least shorted industrial stocks with over $2B market cap [https://seekingalpha.com/news/4540080-most-and-least-shorted-industrial-stocks-with-over-2b-market-cap]