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SYRE (NASDAQ) Stock Analysis | SPYRE THERAPEUTICS INC. – Deepscope
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SYRE Stock Analysis — SPYRE THERAPEUTICS INC. (Healthcare >> Biotechnology)

SYRE FAQ

What is SYRE's ROE?

SPYRE THERAPEUTICS INC. reports a Return on Equity (ROE) of -26.75%.

What is SYRE's dividend yield?

SPYRE THERAPEUTICS INC. offers a dividend yield of 0.00%.

What is SYRE's Quality Score?

Our AI rates SYRE's overall financial quality at 15 out of 100, based on profitability, growth, debt and earnings stability.

Is now a good time to buy SYRE?

Our AI Timing Score for SYRE is 89 out of 100, indicating the relative attractiveness of buying at the current price using technical and momentum signals.

Which sector does SYRE belong to?

SPYRE THERAPEUTICS INC. is classified under the Healthcare >> Biotechnology sector on the NASDAQ exchange

Stock Check   *Daily update data at 8:30 AM*
(Price: 2026-07-31 | FS: 2026-03-31)

SYRE AI Analysis Summary

Our AI summary for SYRE: SPYRE THERAPEUTICS INC. (NASDAQ), Healthcare >> Biotechnology sector. The stock currently trades at a P/E of 0.00, ROE of -26.75%, a dividend yield of 0.00%. Its financial Quality Score stands at 15/100 — fundamentals below the market average. The AI Timing Score is 89/100 — multiple technical signals currently support price momentum. All scores are recomputed automatically after each market close from official exchange data. This is systematically generated analysis, not personalized investment advice.

SYRE

SPYRE THERAPEUTICS INC.
USD 98.33
-3.17 (-3.12%) Day Change
0.14
D/E
-26.8%
ROE
-23.5%
ROA
0.00%
Div Yield
USD 98.33
Price
-3.17 (-3.12%)
Day Change
NEWS SCORE: 94

SYRE, the overall quality is not good ( Quality = 15) but the timing to buy is ...(Sign In to See)...

15

QUALITY

Signal
UNDERPERFORM
Signal Description
Company financial health is Not Good
Reason
ROE is relatively low.
ROA is relatively low.
Acceleration of ROE growth rate is below our criteria.
Historical ROE is relatively low
ROE is decreasing significantly
ROA is too relatively low compare to ROE
Acceleration of ROA growth rate is below our criteria.
Current growth of ROA was below our criteria.
Net profit margin is relatively low.
Acceleration of net profit margin growth rate is below our criteria
Historical net profit margin is relatively low.

88 Sign in

TIMING

Signal
OUTPERFORM
Signal Descri...
Good
Reason
Momentum indicators aligned on the daily timeframe
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In details, quality factors are not good , financial health is not quite good , and ability to make profit is not good , ...

Quality Factors 38%
X
X
X
X
  In Recommendations? Not in any sections
  Select Rate 0.00 From 30 days period
  Watch Rate 0.00 From 30 days period
  News Score 94
  Magic Formula Rank by ROA
N/A
  Magic Formula Rank by ROE
N/A
  Magic Formula Rank by ROIC
N/A
  Price 98.33
  PBV / Sector
13.14 / 5.20
  Earning Per Share -2.00
  PE / Sector
N/A / 19.97
  PEG or PE/Growth / Sector
N/A / 1.22
  Average 1M Daily Value
105.02 M
GREAT
  Average 1W Daily Value
92.58 M
Timing Factors 57%
  MACD
  MACD Signal
  MACD Divergence
  RSI
  Stochastic Oscillator K
  Stochastic Oscillator D
  ADX
  Avg 5 day Timing Score
Financial Health 50%
X
X
X
X
  DE / Sector
  DE Average / Sector
  DE Change Average (%) / Sector
  Current Ratio / Sector
  Current Ratio Average / Sector
  Current Ratio Change Average (%) / Sector
  Quick Ratio / Sector
  Quick Ratio Average / Sector
  Quick Ratio Change Average (%) / Sector
  FCF/Share / Sector
  FCF/Share Average / Sector
  FCF/Share Change Average (%) / Sector
Ability to Make Profit 47%
X
X
X
X
X
X
X
  GPM (%) / Sector
  GPM Average (%) / Sector
  GPM Change Average (%) / Sector
  OPM (%) / Sector
  OPM Average (%) / Sector
  OPM Change Average (%) / Sector
  NPM (%) / Sector
-198.28 / 98.71
  NPM Average (%) / Sector
-16,378.38 / -1,721.76
  NPM Change Average (%) / Sector
N/A / 5,211.62
  Asset Turnover / Sector
  Asset Turnover Average / Sector
  Asset Turnover Change Average (%) / Sector
  ROA (%) / Sector
-23.49 / 27.02
  ROA Average (%) / Sector
-58.91 / -368.17
  ROA Change Average (%) / Sector
-26.33 / 5,404.12
  ROE (%) / Sector
-26.75 / 3.47
  ROE Average (%) / Sector
-87.87 / 6.51
  ROE Change Average (%) / Sector
-22.60 / 2,128.13
  ROIC (%) / Sector
  ROIC Average (%) / Sector
  ROIC Change Average (%) / Sector
Return to Investors 4%
X
  Dividend (%) / Sector
N/A / 0.04
  Dividend Average (%) / Sector
N/A / 17.04
  Dividend Change Average (%) / Sector
N/A / -1.75
Registration Details
X
  Analyze Date 2026-08-01 08:00:33
  Symbol SYRE
  Name SPYRE THERAPEUTICS INC.
  Sector Healthcare >> Biotechnology
  Market NASDAQ
  Listed Shares 86.84 M
  Par Value N/A
  Calculated From Quarter
  Sign N/A
  Market Cap (M.USD) / Sector Average 8,814.39 / 9,903.94
News, Concensus, ...
  Estimation Consensus See at WSJ.com
  Full details See at WSJ.com
  Chart See in Chart feature
  News See at Yahoo Finance

Address: Building 23, Waltham, MA, United States, 02453

Phone: 617 651 5940

Website: https://www.spyre.com

Employees: 112

Sector: Healthcare >> Biotechnology

Description: Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 " anti-TL1A mAbs designed to bind to tumor necrosis factor-like ligand 1A (TL1A). It is also developing SPY003, a clinical-stage program, which is in phase-2 clinical stage designed to bind to interleukin 23 (IL-23); SPY120, a combination of anti-a4ß7 and anti-TL1A mAbs; SPY130, a combination anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. The company was incorporated in 2013 and is based in Waltham, Massachusetts.

Analyst Ratings & Target Price

3 Months Ago
1 Month Ago
Current
Strong Buy
10
10
10
Buy
0
0
0
Hold
1
1
1
Sell
0
0
0
Strong Sell
0
0
0
Consensus
Strong Buy 4.82
Strong Buy 4.82
Strong Buy 4.82
Target Price
USD 90.13
USD 100.47
USD 105.79

Per-Share Earnings, Estimates vs Actuals

Actual
Analyst Range
Estimate

ME vs SECTOR Healthcare >> Biotechnology

SYRE (ME)
Sector Peers
Bubble size = Market Cap

Click a bubble to view stock details  ·  Bubble size represents market capitalization share

Stocks in the Same Sector

Healthcare › Biotechnology

Analysed on the same criteria, ordered by market cap

News

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SYRE
SYRE
USD 98.33 (-3.12%)
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