Maze Therapeutics Stock Still Up 180% After March Tumble. One Fund Just Disclosed Selling $3 Million in Shares

On May 15, 2026, HighVista Strategies disclosed it sold 70,503 shares of Maze Therapeutics(NASDAQ:MAZE) in Q1 2026, an estimated $3.11 million trade based on quarterly average pricing.

What happened

According to a Securities and Exchange Commission (SEC) filing dated May 15, 2026, HighVista Strategies reduced its position in Maze Therapeutics by 70,503 shares during the first quarter. The estimated value of the shares sold was $3.11 million, based on the average closing price for the quarter. The fund ended the period with 99,850 shares, worth $2.98 million.

What else to know

This was a sale, leaving Maze Therapeutics at 0.82% of reported AUM. Top holdings after the filing:

NYSEMKT:DBC: $30.61 million (8.5% of AUM) NASDAQ:ABVX: $12.61 million (3.5% of AUM) NASDAQ:PRAX: $8.48 million (2.3% of AUM) NASDAQ:COGT: $7.58 million (2.1% of AUM) NASDAQ:SYRE: $7.38 million (2.0% of AUM) As of May 14, 2026, shares of Maze Therapeutics were priced at $26.43, up about 180% over the past year and outperforming the S&P 500’s roughly 25% gain in the same period.

Company Overview

Metric Value Market Capitalization $1.40 billion Price (as of market close 2026-05-14) $26.43 Net Income (TTM) ($131.1 million)

Company Snapshot

Maze Therapeutics develops small molecule precision medicines targeting renal, cardiovascular, metabolic diseases, and obesity, with lead programs MZE829 (APOL1 kidney disease, Phase II) and MZE782 (chronic kidney disease, Phase I). The firm operates a clinical-stage biopharmaceutical business model. It develops therapeutics for renal, cardiovascular, metabolic diseases, and obesity in the United States.

Maze Therapeutics, Inc. is a clinical-stage biotechnology company based in South San Francisco, California, focused on developing precision medicines for serious renal and metabolic conditions. The company leverages proprietary genetic insights to advance a pipeline of small molecule therapies, aiming to address unmet medical needs in kidney and related diseases. With ongoing clinical trials and a growing portfolio, Maze Therapeutics seeks to establish a competitive position in the biopharmaceutical sector through innovation and targeted drug development.

What this transaction means for investors

This sale looks less like a classic biotech portfolio rebalance after a huge run. Maze Therapeutics shares have climbed roughly 180% over the past year, and HighVista appears to have locked in some gains while still maintaining exposure to the story.

The interesting part is that the trim comes after Maze reported encouraging Phase 2 data for MZE829, its lead kidney disease candidate. In March, the company said patients in its HORIZON trial saw a 35.6% reduction in proteinuria at week 12, with even stronger results in certain focal segmental glomerulosclerosis patients. Still, the stock crashed over 30% after the news, with investors worrying the drug may not work as well as a rival offering. Either way, Maze now plans to move the drug into a pivotal trial in 2027.

For long-term investors, the key question is whether MZE829’s early kidney disease data can eventually translate into a commercially meaningful therapy. The science is getting stronger, but after such a sharp stock move, expectations are climbing just as fast.

Story Continues

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Jonathan Ponciano has no position in any of the stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy.

Maze Therapeutics Stock Still Up 180% After March Tumble. One Fund Just Disclosed Selling $3 Million in Shares was originally published by The Motley Fool

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